Skeletal morbidity in childhood acute lymphoblastic leukaemia
نویسندگان
چکیده
منابع مشابه
Human parvovirus B19 in childhood acute lymphoblastic leukaemia in Basrah.
OBJECTIVE To investigate the association of human parvovirus B19 infection with the onset of acute lymphoblastic leukaemia and its effect on TEL-AML-1 fusion gene and the presence of mutant P53. METHODS The case-control study was conducted at Basrah Hospital for Paediatrics and Gynaecology, Basrah, Iraq, from May 2009 to April 2010. A total of 100 blood samples were collected from 40 newly di...
متن کاملWhat Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?
The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF...
متن کاملVariable detection of myeloid antigens in childhood acute lymphoblastic leukaemia.
AIMS To determine whether the use of different sources of anti-CD13 and anti-CD33 monoclonal antibodies leads to discrepant results in childhood acute lymphoblastic leukaemia (ALL), which might contribute to the wide variation in the reported incidence of myeloid antigen expressing ALL in childhood. METHODS Stored leukaemic cells from 10 children with previously defined myeloid positive ALL w...
متن کاملBone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary myelofibrosis (SMF) was present at diagnosis in 57% of the cases. It was not statistically significantly related to the prognosis or course of the disease. Thus, although trephine biopsy occasionally provid...
متن کاملMorphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Considerable heterogeneity of lymphoblast morphology in childhood B cell acute lymphoblastic leukaemia has been observed. One case showed unusual monocytic features and emphasised the need for marker studies in the accurate definition of acute lymphoblastic leukaemia phenotypes. B cell acute lymphoblastic leukaemia is rare but may have been previously underestimated by morphological misinterpre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2005
ISSN: 0300-0664,1365-2265
DOI: 10.1111/j.1365-2265.2005.02263.x